Driving across Colorado on US Route 6 offers a journey through dramatic landscapes, historic mountain towns, and vibrant cities. From the red rock mesas near Grand Junction to the wide-open plains leading into Sterling, this stretch of America’s historic highway blends natural beauty with cultural treasures.

Grand Junction – Gateway to Colorado’s Western Slope

Your Colorado adventure begins in Grand Junction, where the Colorado River winds through striking red rock canyons. Known for its vineyards and orchards, the Grand Valley is a place to sample local wines, explore the Colorado National Monument, or stroll downtown’s art-lined streets. It’s the perfect starting point before heading into the Rockies.

Glenwood Springs – Hot Springs and Canyon Views

Following US 6 east, the road runs alongside the Colorado River through Glenwood Canyon, one of the state’s most scenic drives. The town of Glenwood Springs invites travelers to relax in its famous hot springs pools, hike to the stunning Hanging Lake, or visit the historic Hotel Colorado. The mix of natural beauty and small-town charm makes this a memorable stop.

Leadville – High Altitude History

Continuing deeper into the Rockies, US 6 leads to Leadville, once one of the richest silver mining towns in the West. Sitting at over 10,000 feet, Leadville is the highest incorporated city in North America. Visitors can step back in time at the National Mining Hall of Fame and Museum, ride the Leadville Colorado & Southern Railroad, or simply take in the crisp mountain air and panoramic views.
Key details:

• U.S. Route 24: This is the highway that serves Leadville. 
• Historical route change: U.S. 6 was rerouted to go from Wheeler to Glenwood Springs via Redcliffe, bypassing Leadville. 
• U.S. Route 6 today: U.S. 6 runs through Colorado, but it does not go through Leadville. 

Denver – Mile-High Culture

Descending from the mountains, the route reaches Denver, the Mile High City. Here, history meets modern energy: Union Station, the Denver Art Museum, and the lively LoDo District offer plenty to explore. Sports fans can catch a game, while food lovers will enjoy Denver’s booming culinary scene. US 6 slices through the city, connecting travelers directly to the urban heartbeat of Colorado.

Sterling – The Eastern Plains

The final stretch of Colorado’s US 6 passes through the state’s wide-open prairies before reaching Sterling, a friendly town with deep agricultural roots. Sterling’s historic downtown and the Overland Trail Museum provide a window into the past, making it a fitting conclusion to your Colorado road trip.

Traveling US Route 6 across Colorado is more than just a drive—it’s a passage through the state’s diverse identity. From red rock canyons and high mountain passes to vibrant cities and prairie towns, this journey showcases the best of Colorado’s landscapes and communities. Whether you’re soaking in hot springs, walking in mining history, or enjoying Denver’s city lights, Route 6 delivers a road trip rich in discovery.

“Ready to experience Colorado on Route 6? Share this itinerary with a friend, and consider joining the U.S. Route 6 Tourist Association to help preserve America’s historic highway while inspiring future road trips.”